Shuttle expands the capabilities of its chassis, adding support for Mini-ITX motherboards(170 x 170mm or 6.7 x 6.7 inches). Now, the Shuttle chassis can go beyond the Shuttle motherboard. You can easily upgrade the motherboard to your desire.
Ok so if you bought a chassis now then you would need the motherboard with it, but in the future you could use a mini-ITX design.
Other than that there is the Qpack I believe and Antec did a design similar to the one you linked to.